GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs931812 | 1 | rs4734495 | chr8:101917817 | YWHAZ | chr8:101930804-101965623:- | -0.17 | -4.51 | 8.21E-6 | Attention deficit hyperactivity disorder and conduct disorder |
| THCA | cis | rs473651 | 1 | rs473651 | chr2:239335401 | ASB1 | chr2:239335626-239360890:+ | -0.13 | -3.59 | 0.000359 | Multiple system atrophy |
| THCA | cis | rs477692 | 1 | rs473771 | chr10:131408155 | MGMT | chr10:131265454-131565783:+ | 0.39 | 11.66 | 8.39E-28 | Response to temozolomide |
| THCA | cis | rs10760706 | 1 | rs4742777 | chr9:102679173 | STX17 | chr9:102668915-102736817:+ | -0.17 | -4.29 | 2.17E-5 | Alopecia areata |
| THCA | cis | rs10760706 | 1 | rs4742778 | chr9:102701967 | STX17 | chr9:102668915-102736817:+ | -0.17 | -4.29 | 2.21E-5 | Alopecia areata |
| THCA | cis | rs965513 | 1 | rs4743130 | chr9:100546040 | C9orf156 | chr9:100666772-100684852:- | 0.13 | 3.54 | 0.000443 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | cis | rs965513 | 1 | rs4743131 | chr9:100554907 | C9orf156 | chr9:100666772-100684852:- | 0.13 | 3.65 | 0.000295 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | cis | rs16914811 | 1 | rs4743197 | chr9:101067734 | TBC1D2 | chr9:100961281-101018003:- | 0.21 | 5.41 | 1.02E-7 | Schizophrenia |
| THCA | cis | rs16914811 | 1 | rs4743199 | chr9:101067992 | TBC1D2 | chr9:100961281-101018003:- | 0.21 | 5.41 | 1.02E-7 | Schizophrenia |
| THCA | cis | rs7031748 | 1 | rs4743762 | chr9:107592189 | SMC2 | chr9:106856541-106903693:+ | -0.16 | -3.45 | 0.000604 | Myopia (pathological) |
| THCA | cis | rs6479891 | 1 | rs4745706 | chr10:65159580 | LOC84989 | chr10:65224989-65226320:+ | 0.28 | 4.46 | 1.03E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs4745706 | chr10:65159580 | NRBF2 | chr10:64893007-64914785:+ | 0.28 | 4.65 | 4.26E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs4745729 | chr10:65277083 | LOC84989 | chr10:65224989-65226320:+ | 0.27 | 4.22 | 2.88E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs4745729 | chr10:65277083 | NRBF2 | chr10:64893007-64914785:+ | 0.26 | 4.38 | 1.43E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs12220238 | 1 | rs4745740 | chr10:75942469 | VCL | chr10:75754951-75879912:+ | -0.19 | -3.58 | 0.000374 | Soluble interleukin-2 receptor subunit alpha |